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Trying to decrease lipophilicity by incorporating polar functionality may or may not work The potential solubility improvement attendant to introducing polar hydrophilic functionality can easily be more than counterbalanced by a decrease in solubility, because of increased intermolecular crystal packing forces arising from the new polar functionality In our experimental solubility screening, about 60% of poor solubility is unrelated to excessive lipophilicity This 60% of poor solubility arises from high crystal packing forces due to intramolecular interactions in the solid crystal state, which make disruption of the crystal energetically costly So the blunt SAR feature in solubility comes from the phenomenon that solubility improves only gradually (or not at all) as aRelated: .

Theorem: Baker-Campbell-Hausdorff, 154 Boltzmann's H, 74 Carnot's, 12 circle, 210, 212 Clausius', 14 conservation, 97, 99 convex function, 230 equipartition, 137, 138 on Gibbs potential, 24 on Helmholtz free energy, 23 Liouville's, classical, 64 Poincare's, 90 quantized field and N-body system, 480 van Hove's, 22 van Leeuwen's, 168,253, 258 virial,137 of Yang and Lee, 208 Thermal conductivity, 107 Thermal expansion, coefficient of, 21 Thermal wavelength, 184 hermodynamic limit, 206, 207 Third law of thermodynamics, 25, 178, 185,246, 286 Tisza, L., 311 Tmatrix,58 symmetry properties of, 59 Tr~nsfer matrix, 363, 370, 444 Transformation: block-spin, 441 cyclic, 10 quasistatic, 4, 135 renormalization group, 448 reversible, 4 thermodynamic, 4 Transition matrix, see T matrix Tricritical point, 430 Tsui, D. C., 263 Two-fluid model, 311 UWenbeck, G. E., 65, 203, 220, 224, 227, 319 Universality, 397,425 Universality class, 397, 451 Van Alphen, P. M., 260 Van Hove, L., 191. Microsoft Word matrix barcode integrated for microsoft word using .Related: Print EAN-13 Excel , .NET QR Code Generating , UPC-A Generator Excel

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As mentioned earlier, the problem with deriving a new control from an existing Framework control type is that if you access or override any protected members of the base class, you need to have a great deal of insight into what the side effects will be The public members exposed by a control are a lot easier to understand, are better documented, and provide greater protection from introducing unexpected side effects As a result, you'll usually have better success customizing the behavior of Framework data-bound controls from the outside through their public members rather than from the inside through their protected members However, if there are particular customizations you need to make that will be used in more than one location, repeating those customizations in all the forms that use the control is tedious, error-prone, and introduces an unnecessary maintenance burden To avoid this repetition, you can customize the built-in Framework controls through containment in user controls This lets you encapsulate all the customizations inside your user control, so that users of your control don't have to worry about the messy implementation details at all They just focus on the (often simplified) API of your control and add it to as many forms as they like Your user control can contain a collection of Framework controls, custom controls, and custom code to integrate those controls You expose public properties and methods on your user control to enable users of your control to code against it in a fashion similar to the Framework controls Another advantage of taking this approach is that you can use the new BindingSource component to greatly implify exposing data-binding capabilities from your custom control By containing a BindingSource (or several) inside your user control, you can easily hook up external data sources passed in by the users of your custom control, yet still have the built-in mechanisms of the Framework controls and components do all the dirty work for you The following sections develop a custom data-bound user control to demonstrate these concepts and techniques.

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